Genomics

Dataset Information

297

Inhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [ChIP-Seq]


ABSTRACT: Examine the distribution of KDM1A and the histone H3K4me2 mark on chromatin following treatment with two distinct classes of KDM1A inhibitors - an irreversible inhibitor (RN-1) and a reversible inhibitor (GSK690) 15 samples total from two treated cell lines - 9 from Kasumi-1 and 6 from SKNO-1. Controls included were input DNA isolated from the treated cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: John P McGrath   Kaylyn E Williamson  Barbara M Bryant  Charlie Hatton  Patrick Trojer 

PROVIDER: E-GEOD-71739 | ArrayExpress | 2016-02-10

SECONDARY ACCESSION(S): SRP062044GSE71739PRJNA291979

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

McGrath John P JP   Williamson Kaylyn E KE   Balasubramanian Srividya S   Odate Shobu S   Arora Shilpi S   Hatton Charlie C   Edwards Thomas M TM   O'Brien Thomas T   Magnuson Steven S   Stokoe David D   Daniels Danette L DL   Bryant Barbara M BM   Trojer Patrick P  

Cancer research 20160202 7


Lysine-specific demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and repression of gene expression, depending upon context. KDM1A plays an important role in hematopoiesis and was identified as a dependency factor in leukemia stem cell populations. Therefore, we investigated the consequences of inhibiting KDM1A in a panel of cell lines representing all acute myelogenous leukemia (AML) subtypes using selective, reversible and irreversible KDM1A small-  ...[more]

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