Transcriptomics

Dataset Information

296

Differential Gene Expression between MCF10A and MCF7 cells


ABSTRACT: These RNA-seq data were generated to correlate with genomic interaction data in a related Hi-C analysis. MCF10A is a normal-like mammary epithelial cell line and MCF7 is a transformed estrogen responsive breast cancer cell line derived from a metastatic site; both are commonly used in models of breast cancer progression. Analysis revealed a set of genes related to repression of WNT signalling that were both up-regulated in MCF7 and located in genomic regions that had transitioned from closed to open structure in MCF7. RNA-seq of MCF10A and MCF7 cells. 3 replicates each. Sequencing was strand-specific and conducted on ribo-depleted RNA.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jane Lian   Deli Hong  Coralee Tye  Rasim Barutcu  Janet Stein  Gary Stein  Terri Messier  Joe Boyd 

PROVIDER: E-GEOD-71862 | ArrayExpress | 2015-09-02

SECONDARY ACCESSION(S): GSE71862SRP062188PRJNA292330

REPOSITORIES: GEO, ArrayExpress, ENA

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