Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Toshihiro Kobayashi Walfred W Tang Sabine Dietmann Shinseog Kim Kazuhiro Murakami Roopsha Sengupta Azim Surani Ufuk Günesdogan Jan J Zylicz
PROVIDER: E-GEOD-71932 | ArrayExpress | 2016-01-11
SECONDARY ACCESSION(S): GSE71932SRP062264PRJNA292500
REPOSITORIES: GEO, ArrayExpress, ENA
Murakami Kazuhiro K Günesdogan Ufuk U Zylicz Jan J JJ Tang Walfred W C WWC Sengupta Roopsha R Kobayashi Toshihiro T Kim Shinseog S Butler Richard R Dietmann Sabine S Surani M Azim MA
Nature 20160111 7586
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise role is yet unclear. We investigated this in an in vitro model, in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bFGF) and activin A develop as epiblast-like cells (EpiLCs) and gain competence for a PGC-like fate. Consequently, bone morphogenetic protein 4 (BMP4), or ectopic expression of ke ...[more]