Transcriptomics

Dataset Information

295

Differential gene expression profiling of MIHA cells transfected with C-terminal truncated HBx mutants


ABSTRACT: To compare the differentially expressed transcriptomes between MIHA cells transfected with empty vector control or different C-terminal truncated HBx mutants (14 or 35 amino acid carboxyl-terminal truncation - i.e. d14 and d35) mRNA profiles of MIHA cells stably overexpressing empty vector control or different C-terminal truncated HBx mutants (delta 14 and delta 35) were generated by PolyA mRNA sequencing using Illumina HiSeq 1500 platform

ORGANISM(S): Homo sapiens  

SUBMITTER: Chi Ho Lin   Stephanie Ma 

PROVIDER: E-GEOD-71993 | ArrayExpress | 2016-08-02

SECONDARY ACCESSION(S): GSE71993SRP062331PRJNA292690

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.

Ng Kai-Yu KY   Chai Stella S   Tong Man M   Guan Xin-Yuan XY   Lin Chi-Ho CH   Ching Yick-Pang YP   Xie Dan D   Cheng Alfred Sze-Lok AS   Ma Stephanie S  

Oncotarget 20160401 17


Tumor relapse after chemotherapy typifies hepatocellular carcinoma (HCC) and is believed to be attributable to residual cancer stem cells (CSCs) that survive initial treatment. Chronic infection with hepatitis B virus (HBV) has long been linked to the development of HCC. Upon infection, random HBV genome integration can lead to truncation of hepatitis B virus X (HBx) protein at the C-terminus. The resulting C-terminal-truncated HBx (HBx-ΔC) was previously shown to confer enhanced invasiveness an  ...[more]

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