Transcriptomics

Dataset Information

5

Genotyping of human AMP patients using 27 pairs of diagnostic and relapsed AML samples


ABSTRACT: Relapse is the commonest cause of death in acute myeloid leukaemia (AML), but the mechanisms leading to relapse are unclear. Recently, acquisition of segmental uniparental disomy (UPD) by mitotic recombination (MR) has been reported in 15-20% of AML samples at diagnosis using whole genome single nucleotide polymorphism (SNP) arrays. These cytogenetically invisible abnormalities are associated with homozygous mutations in several types of malignancy. Clonal evolution of heterozygous to homozygous mutations by MR could provide a mechanism for relapse. Experiment Overall Design: DNA from 27 pairs of diagnostic and relapsed AML samples were analysed using Affymetrix 10K SNP arrays. The genotype data of relapsed AML were compared with the data from the corresponding presentation AML.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Manoj Raghavan  

PROVIDER: E-GEOD-7210 | ArrayExpress | 2008-06-15

SECONDARY ACCESSION(S): GSE7210PRJNA98303

REPOSITORIES: GEO, ArrayExpress

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