Transcriptomics

Dataset Information

5

Expression data from the aortas of ApoE knockout, ApoE/Caspase-1 double knockout, and wild-type mice


ABSTRACT: Caspase-1 activation senses metabolic danger-associated molecular patterns and mediates the initiation of inflammation. Here, we reported that caspase-1 contributes to hyperlipidemia-induced modulation of vascular cell gene expression during early atherosclerosis in vivo. Our results demonstrate the therapeutic potential of caspase-1 inhibition in the treatment of cardiovascular diseases. All mice were in a C57B/L6 strain background. Male wild-type mice, Apolipoprotein E (ApoE) gene knockout mice, and ApoE/Caspase-1 double gene deficient mice were fed with high fat diet for 3 weeks starting from 8 weeks to induce early dyslipidemia. At 11-week of age, aortas from these mice were used for microarray analysis. 5 biological replicates in each group.

ORGANISM(S): Mus musculus  

SUBMITTER: Ying Yin   Xinyuan Li  Xiao-Feng Yang  Ya-feng Li 

PROVIDER: E-GEOD-72248 | ArrayExpress | 2015-08-21

SECONDARY ACCESSION(S): GSE72248PRJNA293469

REPOSITORIES: GEO, ArrayExpress

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