Transcriptomics

Dataset Information

63

Identification of a portal vessel-associated fetal liver hematopoietic stem cell niche


ABSTRACT: Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow has been characterized, the nature of the fetal liver (FL) niche is not yet elucidated. We show that Nestin+NG2+ pericytes associate with portal vessels, forming a niche promoting HSC expansion. Nestin+NG2+ cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. After closure of the umbilical inlet at birth, portal vessels undergo a transition from Neuropilin-1+Ephrin-B2+ artery to EphB4+ vein phenotype, associated with a loss of peri-portal Nestin+NG2+ cells and emigration of HSCs away from portal vessels. These data support a model in which HSCs are titrated against a peri-portal vascular niche with a fractal-like organization enabled by placental circulation. Characterization of the transcriptome of fetal liver and adult bone marrow niche using RNA-seq

ORGANISM(S): Mus musculus  

SUBMITTER: Jalal Ahmed Khan  Jalal A Khan   Paul Frenette    

PROVIDER: E-GEOD-72341 | ArrayExpress | 2015-12-13

SECONDARY ACCESSION(S): SRP062819GSE72341PRJNA293804

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

| GSE89811 | GEO
2014-05-03 | E-GEOD-48764 | ArrayExpress
2016-06-23 | E-GEOD-61636 | ArrayExpress
2014-04-15 | E-GEOD-55798 | ArrayExpress
2014-03-24 | E-GEOD-55801 | ArrayExpress
2015-08-19 | E-GEOD-57038 | ArrayExpress
2014-04-03 | E-GEOD-43613 | ArrayExpress
| PRJNA274951 | ENA
2014-10-19 | E-GEOD-61695 | ArrayExpress
2014-05-02 | E-MEXP-1107 | ArrayExpress