Transcriptomics

Dataset Information

33

We performed gene expression profiles of human bronchoalveolar epithelial cells (HBEC) transduced with GFP labeled murine focal adhesion kinase (PMX-Purom-GFP-mFAK) or GFP control empty vector counterpart (PMX-Purom-GFP-empty)


ABSTRACT: The goal if this project was to determine the cellular pathways affected by FAK protein overexpression downstream of oncogenic KRAS and RHOA in normal lung epithelium. In addition, we aim to characterize the potential downstream modulators of cell growth and migration upon FAK hyperactivation. We identified pathways in DNA damage, cell growth, apoptosis and cytoskeleton remodeling pertaining to tissue differentiation and carcinogenesis signature respectively. For this study, two duplicate samples were analyzed in triplicate arrays for a total of 6 data poinst per condition. The groups compared were PMX-Purom-GFP-mFAK against PMX-Purom-GFP-emty.

ORGANISM(S): Homo sapiens  

SUBMITTER: Pier P Scaglioni  Jerfiz D Constanzo    

PROVIDER: E-GEOD-72470 | ArrayExpress | 2016-12-28

SECONDARY ACCESSION(S): GSE72470PRJNA294109

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

| GSE73280 | GEO
2015-08-13 | E-GEOD-31986 | ArrayExpress
2011-08-15 | E-GEOD-31140 | ArrayExpress
2015-08-17 | E-GEOD-31986 | ExpressionAtlas
2017-12-06 | PXD007698 | Pride
2011-06-10 | E-GEOD-11149 | ArrayExpress
2008-05-06 | GSE11149 | GEO
| PRJNA127129 | ENA
2012-03-27 | E-GEOD-16466 | ArrayExpress
2014-06-03 | E-GEOD-53618 | ArrayExpress