Dataset Information


RNA-seq of blood cells from 99 systemic lupus erythematosus patients and 18 healthy controls

ABSTRACT: RNA-seq of systemic lupus erythematosus (SLE) whole blood and healthy controls to determine the gene expression changes in these patients. RNA-seq of PAXgene blood from SLE and healthy donors.

ORGANISM(S): Homo sapiens  

SUBMITTER: Tiffany Hung   Tiffany hung  Timothy Behrens  Ward Ortmann  Tushar Bhangale  Christina Chaivoropol  Michael Townsend 

PROVIDER: E-GEOD-72509 | ArrayExpress | 2015-09-16



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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.

Hung T T   Pratt G A GA   Sundararaman B B   Townsend M J MJ   Chaivorapol C C   Bhangale T T   Graham R R RR   Ortmann W W   Criswell L A LA   Yeo G W GW   Behrens T W TW  

Science (New York, N.Y.) 20150917 6259

Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs contribute to disease pathogenesis. We catalogued the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated proinflammatory cytokine secretion by human peripheral blood cells.  ...[more]

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