Genomics

Dataset Information

315

Genome-wide mapping of MYCN binding in neuroblastoma cells


ABSTRACT: To identify the MYCN transcription factor binding sites across the genome, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using anti-MYCN and anti-IgG antibodies on a MYCN-amplified NB cell line, SK-N-BE(2)-C. Identification of MYCN binding in neuroblastoma cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Hsueh-Fen Juan  

PROVIDER: E-GEOD-72640 | ArrayExpress | 2016-05-16

SECONDARY ACCESSION(S): GSE72640SRP063098PRJNA294529

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data.

Hsu Chia-Lang CL   Chang Hsin-Yi HY   Chang Jen-Yun JY   Hsu Wen-Ming WM   Huang Hsuan-Cheng HC   Juan Hsueh-Fen HF  

Oncotarget 20160601 24


MYCN, an oncogenic transcription factor of the Myc family, is a major driver of neuroblastoma tumorigenesis. Due to the difficulty in drugging MYCN directly, revealing the molecules in MYCN regulatory networks will help to identify effective therapeutic targets for neuroblastoma therapy. Here we perform ChIP-sequencing and small RNA-sequencing of neuroblastoma cells to determine the MYCN-binding sites and MYCN-associated microRNAs, and integrate various types of genomic data to construct MYCN re  ...[more]

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