Dataset Information


Effects of MYCN knockdwon on miRNA expression in neuroblastoma cells

ABSTRACT: Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN To identify MYCN-associated miRNAs, we carried out a small RNA-seq on MYCN knockdown in SK-N-BE(2)-C cells to profile the miRNA expression.

ORGANISM(S): Homo sapiens  

SUBMITTER: Hsueh-Fen Juan  

PROVIDER: E-GEOD-72721 | ArrayExpress | 2016-05-16



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Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data.

Hsu Chia-Lang CL   Chang Hsin-Yi HY   Chang Jen-Yun JY   Hsu Wen-Ming WM   Huang Hsuan-Cheng HC   Juan Hsueh-Fen HF  

Oncotarget 20160601 24

MYCN, an oncogenic transcription factor of the Myc family, is a major driver of neuroblastoma tumorigenesis. Due to the difficulty in drugging MYCN directly, revealing the molecules in MYCN regulatory networks will help to identify effective therapeutic targets for neuroblastoma therapy. Here we perform ChIP-sequencing and small RNA-sequencing of neuroblastoma cells to determine the MYCN-binding sites and MYCN-associated microRNAs, and integrate various types of genomic data to construct MYCN re  ...[more]

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