Transcriptomics

Dataset Information

4

Chromatin Remodeler CHD7 mutated in CHARGE Syndrome Interacts with Sox10 to Regulate Timing of CNS Myelination and Remyelination [RNA-seq]


ABSTRACT: Mutations in CHD7, encoding ATP-dependent chromodomain-helicase-DNA-binding protein 7, in CHARGE syndrome leads to multiple congenital anomalies including growth retardation, craniofacial malformations and neurological dysfunction. Currently, mechanisms underlying the CNS phenotypes remain poorly understood. Here, we show that Chd7 is a direct transcriptional target of oligodendrogenesis-promoting factors Olig2 and Brg1 and required for proper timing of CNS myelination and remyelination. Genome-occupancy analyses coupled with transcriptome profiling reveal that Chd7 cooperates with Sox10 to target the enhancers of key myelinogenic genes, and identify novel Chd7 target. 4 RNA-Seq samples from P8 spinal cords of Ctrl and Chd7 cKO mice (duplicatess, Ctrl and cKO)

ORGANISM(S): Mus musculus  

SUBMITTER: Chuntao Zhao   Richard Lu  Danyang He 

PROVIDER: E-GEOD-72726 | ArrayExpress | 2016-02-29

SECONDARY ACCESSION(S): GSE72726SRP063346PRJNA294769

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-72726.idf.txt Idf
E-GEOD-72726.processed.1.zip Processed
E-GEOD-72726.sdrf.txt Txt
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