Transcriptomics

Dataset Information

46

Time-course expression data from HEK293∆RAF1:ER cells stimulated with 4OHT, U0126, CYHX, ActD, EGF, FGF, or IGF


ABSTRACT: We integrate experimental data and mathematical modelling to unveil how ERK signal duration is relayed to mRNA dynamics. HEK293 cells were transfected with an inducible form of RAF (∆RAF1:ER) and induced with tamoxifen (4OHT) or stimulated with different growth factors (EGF, FGF, iGF). Effects of RAF signalling were perturbed subsequently or in parallel with MEK inhibtor U0126, translation inhibtor cycloheximide (CYHX) and actinomycin D (ActD).

ORGANISM(S): Homo sapiens  

SUBMITTER: Florian Uhlitz   Nils Blüthgen 

PROVIDER: E-GEOD-72919 | ArrayExpress | 2017-04-28

SECONDARY ACCESSION(S): GSE72919PRJNA295321

REPOSITORIES: GEO, ArrayExpress

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