Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Baohong Zhao
PROVIDER: E-GEOD-72966 | ArrayExpress | 2016-07-22
SECONDARY ACCESSION(S): GSE72966SRP063630PRJNA295436
REPOSITORIES: GEO, ArrayExpress, ENA
Miller Christine H CH Smith Sinead M SM Elguindy Mahmoud M Zhang Tuo T Xiang Jenny Z JZ Hu Xiaoyu X Ivashkiv Lionel B LB Zhao Baohong B
Journal of immunology (Baltimore, Md. : 1950) 20160509 12
Increased osteoclastogenesis is responsible for osteolysis, which is a severe consequence of inflammatory diseases associated with bone destruction, such as rheumatoid arthritis and periodontitis. The mechanisms that limit osteoclastogenesis under inflammatory conditions are largely unknown. We previously identified transcription factor RBP-J as a key negative regulator that restrains TNF-α-induced osteoclastogenesis and inflammatory bone resorption. In this study, we tested whether RBP-J suppre ...[more]