Dataset Information


Development of gene expression signatures for knockdown of synthetic lethal gene

ABSTRACT: We performed genome-wide expression profiling analysis to define the genes underlying the synthetic-lethal relationship between CBP and p300. We extracted 1,936 genes whose expression levels changed >2-fold upon p300-knockdown (KD) in CBP-KO cells, or upon CBP-KD in p300-KO cells, but not in either KD in wild-type cells Gene expression profile in human lung H1299, H1299 CBP KO, H1299 p300KO cells was measured at 48 hours after transfection of siNT, siCBP or sip300. Two independent experiments were performed at each time (48 hours).

ORGANISM(S): Homo Sapiens

SUBMITTER: Hideaki Ogiwara   Takashi Kohno 

PROVIDER: E-GEOD-73682 | ArrayExpress | 2015-12-12



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Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.

Ogiwara Hideaki H   Sasaki Mariko M   Mitachi Takafumi T   Oike Takahiro T   Higuchi Saito S   Tominaga Yuichi Y   Kohno Takashi T  

Cancer discovery 20151124 4

<h4>Unlabelled</h4>Loss-of-function mutations in the CBP/CREBBP gene, which encodes a histone acetyltransferase (HAT), are present in a variety of human tumors, including lung, bladder, gastric, and hematopoietic cancers. Consequently, development of a molecular targeting method capable of specifically killing CBP-deficient cancer cells would greatly improve cancer therapy. Functional screening of synthetic-lethal genes in CBP-deficient cancers identified the CBP paralog p300/EP300 Ablation of p  ...[more]

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