Dataset Information


TB disease classification

ABSTRACT: Validation of gene expression levels to assess classification of TB patients and healthy controls qPCR gene expression profiling. Whole blood gene expression from TB patients (positive in GenXpert assay) and healthy controls; both tuberculin skin test positive (TSTpos) and -negative (TSTneg).

ORGANISM(S): Homo sapiens  

SUBMITTER: Gayle McEwen   Eric Lader  Stefan H Kaufmann  Jeroen Maertzdorf  John Kenneth 

PROVIDER: E-GEOD-74092 | ArrayExpress | 2015-12-21



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Concise gene signature for point-of-care classification of tuberculosis.

Maertzdorf Jeroen J   McEwen Gayle G   Weiner January J   Tian Song S   Lader Eric E   Schriek Ulrich U   Mayanja-Kizza Harriet H   Ota Martin M   Kenneth John J   Kaufmann Stefan He SH  

EMBO molecular medicine 20160201 2

There is an urgent need for new tools to combat the ongoing tuberculosis (TB) pandemic. Gene expression profiles based on blood signatures have proved useful in identifying genes that enable classification of TB patients, but have thus far been complex. Using real-time PCR analysis, we evaluated the expression profiles from a large panel of genes in TB patients and healthy individuals in an Indian cohort. Classification models were built and validated for their capacity to discriminate samples f  ...[more]

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