Transcriptomics

Dataset Information

297

Enhancers reside in a unique epigenetic environment during early zebrafish development [4C-seq]


ABSTRACT: We describe that during early zebrafish development, DNA methylation has little influence on enhancer activity, and that hypo-methylation is a unique feature of primed enhancers, whereas active enhancers are generally hyper-methylated. Hypo-methylated enhancers (hypo-enhancers) are enriched close to important transcription factors (TFs) that act later in development, are specifically de-methylated before the mid blastula transition (MBT), and reside in a unique epigenetic environment. Finally, we demonstrate that hypo-enhancers are functionally active later in development and that they are physically associated with the transcriptional start site (TSS) of target-genes, irrespective of target-gene activity. We performed 6 different 4C-Seq experiment at two different timepoints and in adult brain.

ORGANISM(S): Danio rerio  

SUBMITTER: lucas kaaij   Lucas Kaaij 

PROVIDER: E-GEOD-74616 | ArrayExpress | 2015-11-06

SECONDARY ACCESSION(S): GSE74616SRP065671PRJNA300969

REPOSITORIES: GEO, ArrayExpress, ENA

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