Transcriptomics

Dataset Information

3

Gene Expression Profiling of IL-17A-treated Synovial Fibroblasts from the Human Temporomandibular Joint


ABSTRACT: Synovial fibroblasts contribute to the inflammatory temporomandibular joint under pathogenic stimuli. Synovial fibroblasts and T cells participate in the perpetuation of joint inflammation in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other. IL-17 is an inflammatory cytokine produced primarily by Th17 cells that plays critical roles in the pathogenesis of numerous autoimmune and inflammatory diseases. Here, we investigated the roles of IL-17A in temporomandibular joint disorders (TMD) by using genome-wide analysis of synovial fibroblasts isolated from patients with TMD. We analyzed the gene expression profiles of synovial fibroblasts that were treated with or without IL-17A. IL-17 induced gene expression in synovial fibroblasts from human temporomandibular joint was measured at 4 hours after treated with IL-17A (10 ng/ml) and untreated control samples. This experiment used one donor sample.

ORGANISM(S): Homo sapiens  

SUBMITTER: Mutsumi Kawashima   Miwa Akutsu  Suguru Watanabe  Naomi Ogura  Toshirou Kondoh  Toshio Hattori  Ko Ito 

PROVIDER: E-GEOD-74668 | ArrayExpress | 2015-11-05

SECONDARY ACCESSION(S): GSE74668PRJNA301133

REPOSITORIES: GEO, ArrayExpress

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