Transcriptomics

Dataset Information

6

G0S2 functions as a tumor supressor through represssion of Myc signaling pathways


ABSTRACT: Comparions on gene expression in murine embyonic fibroblasts (MEFs) wild-type vs G0S2 null MEFs Total RNA obtained from spontanously immortalized MEF cell line E2 from wild-type C57BL/6 mice (E2) and spontaneously immortalized MEF cell line E6 from G0S2 knockout C57BL/6 mice; MEF lines were used at passage number 10-12

ORGANISM(S): Mus musculus  

SUBMITTER: Michael Spinella   Christina Y Yim  Michael J Spinella 

PROVIDER: E-GEOD-74696 | ArrayExpress | 2016-06-01

SECONDARY ACCESSION(S): GSE74696PRJNA301170

REPOSITORIES: GEO, ArrayExpress

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Publications

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program.

Yim Christina Y CY   Sekula David J DJ   Hever-Jardine Mary P MP   Liu Xi X   Warzecha Joshua M JM   Tam Janice J   Freemantle Sarah J SJ   Dmitrovsky Ethan E   Spinella Michael J MJ  

Cancer research 20160202 5


Methylation-mediated silencing of G0-G1 switch gene 2 (G0S2) has been detected in a variety of solid tumors, whereas G0S2 induction is associated with remissions in patients with acute promyelocytic leukemia, implying that G0S2 may possess tumor suppressor activity. In this study, we clearly demonstrate that G0S2 opposes oncogene-induced transformation using G0s2-null immortalized mouse embryonic fibroblasts (MEF). G0s2-null MEFs were readily transformed with HRAS or EGFR treatment compared with  ...[more]

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