Transcriptomics

Dataset Information

121

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression]


ABSTRACT: Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence. Identify the KDM2B dependent transcriptome in human leukemia cell lines by using the GeneChip® PrimeView™ Human Gene Expression Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Yan Kai   Alexandros Tzatsos 

PROVIDER: E-GEOD-74959 | ArrayExpress | 2016-02-22

SECONDARY ACCESSION(S): GSE74959PRJNA302011

REPOSITORIES: GEO, ArrayExpress

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Publications

Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.

Andricovich Jaclyn J   Kai Yan Y   Peng Weiqun W   Foudi Adlen A   Tzatsos Alexandros A  

The Journal of clinical investigation 20160125 3


The development of the hematopoietic system is a dynamic process that is controlled by the interplay between transcriptional and epigenetic networks to determine cellular identity. These networks are critical for lineage specification and are frequently dysregulated in leukemias. Here, we identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells (HSPCs). RNA sequencing of Kdm2b-null HSPCs and  ...[more]

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