Transcriptomics,Multiomics

Dataset Information

83

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (microarray)


ABSTRACT: DHS enahncers identify novel pathways in OB differentiation We examined gene expression and compared to DHS on promoters and enhancers during OB differentiation

ORGANISM(S): Homo sapiens  

SUBMITTER: Gordon L Hager  Lyuba Varticovski   Songjoon Baek   Bethtrice Thompson    

PROVIDER: E-GEOD-75230 | ArrayExpress | 2016-02-27

SECONDARY ACCESSION(S): GSE75230PRJNA302852

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation.

Thompson Bethtrice B   Varticovski Lyuba L   Baek Songjoon S   Hager Gordon L GL  

PloS one 20160218 2


Bone continuously undergoes remodeling by a tightly regulated process that involves osteoblast differentiation from Mesenchymal Stem Cells (MSC). However, commitment of MSC to osteoblastic lineage is a poorly understood process. Chromatin organization functions as a molecular gatekeeper of DNA functions. Detection of sites that are hypersensitive to Dnase I has been used for detailed examination of changes in response to hormones and differentiation cues. To investigate the early steps in commit  ...[more]

Similar Datasets

2016-02-27 | E-GEOD-75232 | ArrayExpress
2016-04-03 | E-GEOD-79654 | ArrayExpress
2017-09-23 | E-MTAB-1975 | ArrayExpress
2017-09-23 | E-MTAB-1585 | ArrayExpress
2016-02-27 | E-GEOD-75231 | ArrayExpress
2014-06-03 | E-GEOD-50860 | ArrayExpress
2016-04-03 | E-GEOD-79650 | ArrayExpress
2014-05-03 | E-MTAB-429 | ArrayExpress
2012-06-25 | E-GEOD-31691 | ArrayExpress
2014-05-13 | E-GEOD-43100 | ArrayExpress