Transcriptomics

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Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (microarray)


ABSTRACT: DHS enahncers identify novel pathways in OB differentiation We examined gene expression and compared to DHS on promoters and enhancers during OB differentiation

ORGANISM(S): Homo sapiens  

SUBMITTER: Gordon L Hager   Lyuba Varticovski  Songjoon Baek  Bethtrice Thompson 

PROVIDER: E-GEOD-75230 | ArrayExpress | 2016-02-20

SECONDARY ACCESSION(S): GSE75230PRJNA302852

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation.

Thompson Bethtrice B   Varticovski Lyuba L   Baek Songjoon S   Hager Gordon L GL  

PloS one 20160218 2


Bone continuously undergoes remodeling by a tightly regulated process that involves osteoblast differentiation from Mesenchymal Stem Cells (MSC). However, commitment of MSC to osteoblastic lineage is a poorly understood process. Chromatin organization functions as a molecular gatekeeper of DNA functions. Detection of sites that are hypersensitive to Dnase I has been used for detailed examination of changes in response to hormones and differentiation cues. To investigate the early steps in commit  ...[more]

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