Transcriptomics

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Genome-wide analysis of gefitinib short-term resistance gene expression in the NSCLC cell line PC9 in co-culture


ABSTRACT: Analysis of gefitinib short-term resistance at gene expression level. The hyposthesis tested in the present study was that short-term resistance towards gefitinib in NSCLC cells influences pathways that associates with resistance towards EGFR-TKI treatment. Results provide important information of the response of EGFR mutant NSCLC cells to gefitinib and also to resistance towards gefitinib resistance, up-or down-regulated specific resistance pathways and cellular functions. Total RNA obtained from PC9 cell line (n=3), co-cultured PC9 (with MRC-5 cells)(n=3), gefitinib treated (0.5µM) PC9 (n=3), and co-cultured (MRC-5) + gefitinib treated PC9 cells (n=3) for 48h after gefitinib treatment

ORGANISM(S): Homo sapiens  

SUBMITTER: Sajo Kaduthanam  

PROVIDER: E-GEOD-75308 | ArrayExpress | 2016-07-01

SECONDARY ACCESSION(S): GSE75308PRJNA303163

REPOSITORIES: GEO, ArrayExpress

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