Transcriptomics

Dataset Information

306

RNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system


ABSTRACT: 5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse populations of oligodendrocytes, and revealing dynamics of oligodendrocyte maturation. 5069 individual cells were sampled from CNS regions of mice of various strains as detailed in the protocols section

ORGANISM(S): Mus musculus  

SUBMITTER: Sten Linnarsson   Amit Zeisel  Sueli Marques  Gonçalo Castelo-Branco 

PROVIDER: E-GEOD-75330 | ArrayExpress | 2016-06-10

SECONDARY ACCESSION(S): SRP066613GSE75330PRJNA303966

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, wh  ...[more]

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