Transcriptomics

Dataset Information

3

Transcriptomic study of hepatocarcinoma cells exposed to sorafenib


ABSTRACT: sorafenib is the treatment of reference for hepatocellular carcinoma (HCC). We applied sorafenib on the human HCC cell line Huh7 and the subclone shRb, carrying a stable knock-down of the expression of the RB1 gene, a key regulator of liver carcinogenesis. Our aim was to better understand the physiologic and metabolic consequences of the exposure of HCC cells to sorafenib. We used microarrays to detail the global programme of gene expression at an early time point (9h) after exposure to sorafenib Whole-genome microarrays were used to study the transcriptome of Huh7 cells exposed to Sorafenib

ORGANISM(S): Homo sapiens  

SUBMITTER: Shinichiro Takahashi   Bruno Chauffert  Christophe Louandre  Jean-marc Régimbeau  Aline Houessinon  Catherine François  Laurent Gutierrez  Nathalie Ganne  Antoine Galmiche  Zuzanna Saidak  Sandra Bodeau  Chloé Sauzay  Nathalie Barget  Corinne Godin  Gaëlle Mongelard 

PROVIDER: E-GEOD-75620 | ArrayExpress | 2016-06-30

SECONDARY ACCESSION(S): GSE75620PRJNA304751

REPOSITORIES: GEO, ArrayExpress

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