Transcriptomics

Dataset Information

3

The study of inflammatory responses in mammalian macrophages with LPS stimulation


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Aravind Tallam  

PROVIDER: E-GEOD-76563 | ArrayExpress | 2016-02-24

SECONDARY ACCESSION(S): GSE76563PRJNA307977

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages.

Tallam Aravind A   Perumal Thaneer M TM   Antony Paul M PM   Jäger Christian C   Fritz Joëlle V JV   Vallar Laurent L   Balling Rudi R   Del Sol Antonio A   Michelucci Alessandro A  

PloS one 20160212 2


Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic acid from cis-aconitic acid, a tricarboxylic acid (TCA) cycle intermediate. Itaconic acid possesses specific antimicrobial properties inhibiting isocitrate lyase, the first enzyme of the glyoxylate shunt  ...[more]

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