Transcriptomics

Dataset Information

39

RNA-seq of pre-treatment and post-relapse matched samples from melanoma patients


ABSTRACT: RNA-seq of pre-treatment and post-relapse matched samples from melanoma patients RNA-seq was performed for matched samples before treatment and after relapse from six patients that have been treated with RAF or RAF+MEK inhibitors. Submitter declares that raw sequence data will be submitted to dbGaP due to patient privacy concerns.

ORGANISM(S): Homo sapiens  

SUBMITTER: Itay Tirosh  Eliezer Van Allen    

PROVIDER: E-GEOD-77940 | ArrayExpress | 2016-02-26

SECONDARY ACCESSION(S): GSE77940PRJNA312167

REPOSITORIES: GEO, ArrayExpress

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Publications


Treatment of BRAF-mutant melanoma with combined dabrafenib and trametinib, which target RAF and the downstream MAP-ERK kinase (MEK)1 and MEK2 kinases, respectively, improves progression-free survival and response rates compared with dabrafenib monotherapy. Mechanisms of clinical resistance to combined RAF/MEK inhibition are unknown. We performed whole-exome sequencing (WES) and whole-transcriptome sequencing (RNA-seq) on pretreatment and drug-resistant tumors from five patients with acquired res  ...[more]

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