Transcriptomics

Dataset Information

45

Expression data from IMQ-induced psoriasis-like skin inflammation in miR-146a-/- and C57BL6J mice


ABSTRACT: miR-146a acts as a negative feedback regulator of inflammation. To investigate the role of miR-146a in psoriasis psoriasiform skin inflammation was indeuced in Mir-146a-/- and wild type mice (C57BL6J) by topical applciation of imiquimod (IMQ)-cream (Aldara). Gene expression profiling (Affymetrix) was used to identify transcriptomic changes associated with psoriasis-like skin inflammation in wild type vs. miR-146a -/-mice. A daily topical dose of 31.25 mg of Aldara cream (5% IMQ) was applied on the right ear of miR-146a -/- and C57BL/6 mice on three consecutive days to induce psorisis-like skin inflammation. Mice were sacrificed at day 4. Ear flaps were collected for total RNA extraction and hybridization on Affymatrix GeneTitan plate format Gene ST 2.1 (mouse).

ORGANISM(S): Mus musculus  

SUBMITTER: Andor Pivarcsi  Enikö Sonkoly   Ankit Srivastava    

PROVIDER: E-GEOD-78057 | ArrayExpress | 2016-02-27

SECONDARY ACCESSION(S): GSE78057PRJNA312479

REPOSITORIES: GEO, ArrayExpress

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