Dataset Information


Multi-organ mapping of cancer risk

ABSTRACT: Cancers are distributed unevenly across the body; but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used cre-recombination of conditional lineage tracing, oncogene and tumour suppressor alleles to define populations of stem and non-stem cells in mouse organs, and test their life-long susceptibility to tumorigenesis. We show that cancer risk is determined by the life-long generative capacity of mutated cells. This relationship held true in the presence of multiple genotypes and regardless of developmental stage, strongly supporting the notion that stem cells dictate organ cancer risk. Using the liver as a model system, we further show that damage-induced activation of stem cell function markedly increases cancer risk. Therefore, we propose that a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of these cell populations, creates a ‘perfect storm’ that ultimately determines organ cancer risk. Long-term lineage tracing and conditional oncogenic targeting of Prom1-expressing cells in various mouse organs.

ORGANISM(S): Mus musculus  

SUBMITTER: Sarah Utley   David W Ellison  David Finkelstein  Geoffrey Neale  Lei Shi  Stanely B Pounds  Yongdong Wang  Culian L Gao  Liqin Zhu  Arzu Onar-Thomas  Richard J Gilbertson  Dolores López-Terrada  Kasper S Wang 

PROVIDER: E-GEOD-78076 | ArrayExpress | 2016-07-01



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