Genomics

Dataset Information

301

Genome-wide maps of chromatin state during cardiac reprogramming of human fibroblasts by small molecules


ABSTRACT: Cardiomyocyte-like cells can be reprogrammed from somatic fibroblasts by overexpression of cardiac genes, providing a new avenue for cardiac regenerative therapy. Here we report an alternative approach in which functional cardiomyocytes can be rapidly and efficiently generated from human fibroblasts by a specific combination of small molecules. ChIP-seq analysis has been used to understand the dynamic changes in chromatin state during early stage of reprogramming. We analyzed the genome-wide epigenetic changes by ChIP-seq analysis of H3K4me3 and H3K27ac (active chromatin marks) and H3K27me3 (inactive chromatin mark) at reprogramming Day 6 (D6) and day 11 (D11).

ORGANISM(S): Homo sapiens  

SUBMITTER: Sheng Ding   Nan Cao  Jiashun Zheng 

PROVIDER: E-GEOD-78096 | ArrayExpress | 2016-02-19

SECONDARY ACCESSION(S): SRP070556GSE78096PRJNA312598

REPOSITORIES: GEO, ArrayExpress, ENA

Similar Datasets

2013-01-11 | E-GEOD-43415 | ArrayExpress
2014-06-12 | E-GEOD-58100 | ArrayExpress
2014-07-08 | E-GEOD-47843 | ArrayExpress
2012-11-26 | E-GEOD-40129 | ArrayExpress
2015-09-16 | E-GEOD-59518 | ArrayExpress
2011-01-03 | E-GEOD-19065 | ArrayExpress
2012-09-14 | E-GEOD-38587 | ArrayExpress
2013-08-01 | E-GEOD-49390 | ArrayExpress
2014-10-07 | E-GEOD-59828 | ArrayExpress
2014-05-19 | E-GEOD-49621 | ArrayExpress