Transcriptomics

Dataset Information

4

Expression data from peritoneal macrophages stimulated with lipid A


ABSTRACT: Setdb1 is one of the H3K9 methyltransferases and represses gene expression by H3K9 methylation. In an attempt to elucidate the role of Setdb1 in the TLR4-mediated inflammatory responses, we performed DNA microarray analysis using lipid A (the active component of LPS)-stimulated peritoneal macrophages from macrophage specific Setdb1 KO (KO) and WT mice. The genes upregulated by lipid A treatment in WT macrophages and further increased in KO macrophages contain many genes associated with interleukins and chemokines. Peritoneal macrophages from WT and KO mice were stimulated with lipid A 10 ng/ml or vehicle for 4 h. Microarray analysis was performed using Affymetrix Mouse 430 2.0.

ORGANISM(S): Mus musculus  

SUBMITTER: Rumi Hachiya   Yoshihiro Ogawa  Takayoshi Suganami  Yoshihiro Miyamamoto 

PROVIDER: E-GEOD-78153 | ArrayExpress | 2016-06-27

SECONDARY ACCESSION(S): GSE78153PRJNA312789

REPOSITORIES: GEO, ArrayExpress

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