Dataset Information


Angiogenesis study of Gd@C82(OH)22 nanoparticle

ABSTRACT: we report a novel nanomedicine (Gd@C82(OH)22 ) effectively inhibit human breast tumor growth by antiangiogenesis in vivo. To further identify which angiogenic factor(s) were affected on mRNA level, the "RT² Profiler™ PCR Array Mouse Angiogenesis (APMM-024, SuperArray Bioscience Corporation)" was used. Keywords: nanomedicine, Gd@C82(OH)22, angiogenesis, MCF-7, breast cancer In the experimental group, the tumor bearing mice were administered intraperitoneally (i.p.) [Gd@C82(OH)22]n saline solution once a day at the dose of 2.5mM/kg, after the tumor tissue implantation into the animal for 7 days, continuing until the mice were sacrificed. The 0.9% saline soultion was used as control. At the end of the experiment, parts of the tumor tissue was collected, and further be analyzed by PCR-array.

ORGANISM(S): Musculus  

SUBMITTER: Zhen Chen   Xuxia Wang  Xingjie Liang  Hao Lei  Gengmei Xing  Ning Zhang  Huan Meng  Chunying Chen  Hui Yuan  Chengcheng Zhang  Yuliang Zhao  Feng Zhao 

PROVIDER: E-GEOD-7861 | ArrayExpress | 2009-04-01



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