Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Tony Kwan Jacek Majewski
PROVIDER: E-GEOD-7952 | ArrayExpress | 2007-08-07
SECONDARY ACCESSION(S): GSE7952PRJNA100135
REPOSITORIES: GEO, ArrayExpress
Kwan Tony T Benovoy David D Dias Christel C Gurd Scott S Serre David D Zuzan Harry H Clark Tyson A TA Schweitzer Anthony A Staples Michelle K MK Wang Hui H Blume John E JE Hudson Thomas J TJ Sladek Rob R Majewski Jacek J
Genome research 20070801 8
Alternative pre-mRNA splicing increases proteomic diversity and provides a potential mechanism underlying both phenotypic diversity and susceptibility to genetic disorders in human populations. To investigate the variation in splicing among humans on a genome-wide scale, we use a comprehensive exon-targeted microarray to examine alternative splicing in lymphoblastoid cell lines (LCLs) derived from the CEPH HapMap population. We show the identification of transcripts containing sequence verified ...[more]