Dataset Information


Hypothalamic transcriptome of male mice on high fat diet, from 99 strains

ABSTRACT: Previous studies had shown that integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mouse Diversity Panel (HMDP), a reference resource population for cardiovascular and metabolic traits. We report numerous novel transcripts supported by proteomic analyses, as well as novel non coding RNAs. High resolution genetic mapping of transcript levels in HMDP, reveals both local and trans expression Quantitative Trait Loci (eQTLs) demonstrating 2 trans eQTL "hotspots" associated with expression of hundreds of genes. We also report thousands of alternative splicing events regulated by genetic variants. Finally, comparison with about 150 metabolic and cardiovascular traits revealed many highly significant associations. Our data provides a rich resource for understanding the many physiologic functions mediated by the hypothalamus and their genetic regulation. 282 samples, 3 biological replicates per strain

ORGANISM(S): Mus musculus  

SUBMITTER: Yehudit Hasin-Brumshtein   Desmond Smith  Aldons J Lusis 

PROVIDER: E-GEOD-79551 | ArrayExpress | 2016-03-24



Dataset's files

Action DRS Other
E-GEOD-79551.idf.txt Idf
E-GEOD-79551.sdrf.txt Txt
Items per page:
1 - 3 of 3

Similar Datasets

2016-01-01 | S-EPMC5053804 | BioStudies
2019-01-01 | S-EPMC6812340 | BioStudies
1000-01-01 | S-EPMC3586763 | BioStudies
2013-01-01 | S-EPMC3933005 | BioStudies
2019-01-01 | S-EPMC6753136 | BioStudies
2015-01-01 | S-EPMC4687930 | BioStudies
2018-04-10 | GSE112947 | GEO
2020-01-01 | S-EPMC7763884 | BioStudies
2011-01-01 | S-EPMC3192952 | BioStudies
2011-01-01 | S-EPMC3072371 | BioStudies