Transcriptomics

Dataset Information

3

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas


ABSTRACT: DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be found in tumour tissue from a single uniform subsite, the oral tongue. The methylation status of 83 comprehensively annotated oral tongue squamous cell carcinoma (OTSCC) formalin-fixed paraffin-embedded (FFPE) samples from a single institution were examined with the Illumina HumanMethylation450K (HM450K) array. 83 FFPE primary OTSCC tumour samples were analysed in one experimental run.

ORGANISM(S): Homo sapiens  

SUBMITTER: Nicholas C Wong   Benjamin Solomon  Annette M Lim  Danny Rischin 

PROVIDER: E-GEOD-79556 | ArrayExpress | 2016-07-18

SECONDARY ACCESSION(S): GSE79556PRJNA316156

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas.

Lim Annette M AM   Wong Nicholas C NC   Pidsley Ruth R   Zotenko Elena E   Corry June J   Dobrovic Alexander A   Clark Susan J SJ   Rischin Danny D   Solomon Benjamin B  

Clinical epigenetics 20160718


DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be found in tumour tissue from a single uniform subsite, the oral tongue. The methylation status of 109 comprehensively annotated oral tongue squamous cell carcinoma (OTSCC) formalin-fixed paraffin-embedded (FFPE) samples from a single institution were examined with the Illumina HumanMethylatio  ...[more]

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