Transcriptomics

Dataset Information

63

Sigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages


ABSTRACT: Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity and function (i.e., detoxification and secretion). Keywords: strains comparison We compared the global gene expression of the H37Rv strain and the sigE mutant strain of Mtb in different conditions: growing exponentially in liquid media; after 2h of incubation in RPMI; or after 24 hours of infection of human macrophage-like THP-1 cells.

ORGANISM(S): Mycobacterium tuberculosis  

SUBMITTER: Virginie Aris   Richard Pine   Issar Smith   Analia Trevani  María E Alvarez  Virginie Marie Aris  Saleena Ghanny  Patricia Fontan  Jeff Cheng  Patricia Soteropoulos 

PROVIDER: E-GEOD-7962 | ArrayExpress | 2010-05-25

SECONDARY ACCESSION(S): GSE7962PRJNA105505

REPOSITORIES: GEO, ArrayExpress

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Publications

Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.

Fontán Patricia A PA   Aris Virginie V   Alvarez María E ME   Ghanny Saleena S   Cheng Jeff J   Soteropoulos Patricia P   Trevani Analia A   Pine Richard R   Smith Issar I  

The Journal of infectious diseases 20080901 6


Mycobacterium tuberculosis survives in macrophages and usually subverts the bactericidal mechanisms of these phagocytes. The understanding of this host-pathogen interaction is relevant for the development of new treatments for tuberculosis. The adaptation of M. tuberculosis to intracellular life depends on its ability to regulate the expression of its genes. Sigma factors are important bacterial transcription activators that bind to the RNA polymerase and give it promoter specificity. Sigma fact  ...[more]

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