Transcriptomics

Dataset Information

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ShRNA cassette sequencing from disomic and trisomic fibroblasts cultured in the presence of shRNA kinome library for 14 days


ABSTRACT: Kinome-wide shRNA screen to identify kinases differentially required for survival of cells disomic and trisomic for chromosome 21 Cells were transduced in triplicate and propagated for 14 days to allow for enrichement or depletion of shRNAs from the population

ORGANISM(S): Homo sapiens  

SUBMITTER: Ahwan Pandey   Kelly D Sullivan  Leisa P Jackson  Joaquín M Espinosa 

PROVIDER: E-GEOD-79840 | ArrayExpress | 2016-07-29

SECONDARY ACCESSION(S): GSE79840SRP072768PRJNA317171

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells s  ...[more]

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