Transcriptomics

Dataset Information

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Response to low-dose cortisol treatment in zebrafish embryos [larvae]


ABSTRACT: Chronic early life stress increases adult susceptibility to numerous health problems linked to chronic inflammation. One way that this may occur is via glucocorticoid-induced developmental programming. To gain insight into such programming we treated zebrafish embryos with 1 micromolar cortisol and examined the effects on larvae. Treated larvae had elevated whole-body cortisol and glucocorticoid signaling, and up-regulated genes associated with defense response and immune system processes. 6 samples total were analyzed. 3 DMSO controls, and 3 cortisol treated (1 micromolar).

ORGANISM(S): Danio rerio  

SUBMITTER: Benjamin L King   Shusen Zhu  James A Coffman  Ellen I Hartig 

PROVIDER: E-GEOD-80221 | ArrayExpress | 2016-06-01

SECONDARY ACCESSION(S): GSE80221SRP073217PRJNA318296

REPOSITORIES: GEO, ArrayExpress, ENA

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