Transcriptomics

Dataset Information

362

Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa


ABSTRACT: Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent Virulent Rickettsia rickettsii R strain in triplicate was compared to avirulent Rickettsia rickettsii Iowa in triplicate

ORGANISM(S): Rickettsia rickettsii  

SUBMITTER: Ted Hackstadt   Stephen F Porcella  Dan Sturdevant  Damon W Ellison  Daniel E Sturdevant  Tina R Clark  Kimmo Virtaneva 

PROVIDER: E-GEOD-8041 | ArrayExpress | 2010-05-26

SECONDARY ACCESSION(S): GSE8041PRJNA100859

REPOSITORIES: GEO, ArrayExpress

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Publications

Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa.

Ellison Damon W DW   Clark Tina R TR   Sturdevant Daniel E DE   Virtaneva Kimmo K   Porcella Stephen F SF   Hackstadt Ted T  

Infection and immunity 20071119 2


Rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of Rocky Mountain spotted fever. To identify genes involved in the virulence of R. rickettsii, the genome of an avirulent strain, R. rickettsii Iowa, was sequenced and compared to the genome of the virulent strain R. rickettsii Sheila Smith. R. rickettsii Iowa is avirulent in a guinea pig model of infection and displays altered plaque morphology with decreased lysis of infected host cells. Comparison of the t  ...[more]

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