Transcriptomics

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Genomic landscape affected by allelic imbalance in the cancerization filed of normal appearing airway


ABSTRACT: Normal appearing airway samples from non-small cell lung (NSCLC) cancer patients were profiled using illumina sequencing arrays. Allelic imbalance was detected in normal-appearing large and small airway samples and affected known lung cancer driver genes. Multiple airway samples from 45 patients were analyzed using illumina sequencing arrays in order to comprehensively asses the genomic landscape of airway epithelia adjacent to NSCLC. For each patients there was at least one small airway sample, a tumor samples, as well as germline control sample (blood and/or normal uninvolved lung). In addition to these samples additional samples were analyzed for a subset of patients these included large airway, nasal, and multiple core needle biopsies from the tumor.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yasminka Aleksandra Jakubek   Paul Scheet  Yasminka Jakubek  Humam Kadara 

PROVIDER: E-GEOD-80519 | ArrayExpress | 2016-08-10

SECONDARY ACCESSION(S): GSE80519PRJNA319250

REPOSITORIES: GEO, ArrayExpress

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Publications


Visually normal cells adjacent to, and extending from, tumors of the lung may carry molecular alterations characteristics of the tumor itself, an effect referred to as airway field of cancerization. This airway field has been postulated as a model for early events in lung cancer pathogenesis. Yet the genomic landscape of somatically acquired molecular alterations in airway epithelia of lung cancer patients has remained unknown. To begin to fill this void, we sought to comprehensively characteriz  ...[more]

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