Transcriptomics

Dataset Information

4

Transcriptional response to the HSP70 inhibitor MAL3-101 in parental rhabdomyosarcoma cells and isogenic acquired-resistance lines.


ABSTRACT: We demonstrate that inhibition of HSP70 with MAL3-101 induces activation of the unfolded protein response, and that cells with acquired resistance upregulate a cytosolic HSP70 at the level of mRNA. Whole transcriptome sequencing was undertaken of parental or acquired-resistance RMS13 cells treated with either DMSO or 10 micromolar MAL3-101.

ORGANISM(S): Homo sapiens  

SUBMITTER: Amit J Sabnis   Trever G Bivona 

PROVIDER: E-GEOD-80525 | ArrayExpress | 2016-05-15

SECONDARY ACCESSION(S): GSE80525SRP073662PRJNA319193

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-80525.idf.txt Idf
E-GEOD-80525.processed.1.zip Processed
E-GEOD-80525.sdrf.txt Txt
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