Transcriptomics

Dataset Information

298

Transcriptomic analysis of inter- and intra-patient variation in human iPSC cardiomyocytes: Platform for precision medicine to predict drug toxicity


ABSTRACT: In the present study we created and analyzed cardiomyocytes from two separate iPSC clones from the fibroblasts of five different female individuals and two male individuals, using footprint-free Sendai virus RNA-seq of iPSC cardiomyocytes, Ampli-seq of heart left ventricle and iPSC cardiomyocytes (with and without drug treatment) and Exome-seq of patient fibroblasts.

ORGANISM(S): Homo sapiens  

SUBMITTER: Joseph C Wu   Paul W Burridge  Joseph Wu  Ningyi Shao  Elena Matsa  Kun-Hsing Yu 

PROVIDER: E-GEOD-83668 | ArrayExpress | 2016-08-24

SECONDARY ACCESSION(S): GSE83668SRP077009PRJNA326668

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) enable the study of pharmacological and toxicological responses in patient-specific cardiomyocytes (CMs) and may serve as preclinical platforms for precision medicine. Transcriptome profiling in hiPSC-CMs from seven individuals lacking known cardiovascular disease-associated mutations and in three isogenic human hea  ...[more]

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