Transcriptomics

Dataset Information

101

Transcription profiling of human Parkinsons medial and substania nigra


ABSTRACT: Affymetrix HG_U133 array sets (A and B chips) were used to determine the whole genome transcription profile of clinically documented and neuropathologically confirmed cases of sporadic Parkinson's disease as well as controls. Experiment Overall Design: Post mortem brain tissue samples from Parkinson's disease and control cases (substantia nigra, split into medial and lateral portions, and frontal cortex) were prepared for this study. In total, 47 individual tissue samples were analyzed using one A and one B GeneChip per sample, i.e. 15 samples of medial parkinsonian SN, 9 samples of lateral parkinsonian SN, 8 medial nigra control samples and 7 lateral nigra control samples. Lateral and medial nigra samples were from the same cases. In addition, frontal cerebral cortex was analyzed in five of the PD cases and in three of the controls (Neurogenetics 2006 7: 1–11; Acta Neuropathologica (Berlin) 2007 113: 253-263

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Linda B. Moran 

PROVIDER: E-GEOD-8397 | ArrayExpress | 2008-06-16

SECONDARY ACCESSION(S): GSE8397PRJNA101445

REPOSITORIES: GEO, ArrayExpress

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Publications

Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease.

Moran L B LB   Duke D C DC   Deprez M M   Dexter D T DT   Pearce R K B RK   Graeber M B MB  

Neurogenetics 20060112 1


We have used brain tissue from clinically well-documented and neuropathologically confirmed cases of sporadic Parkinson's disease to establish the transcriptomic expression profile of the medial and lateral substantia nigra. In addition, the superior frontal cortex was analyzed in a subset of the same cases. DNA oligonucleotide microarrays were employed, which provide whole human genome coverage. A total of 570 genes were found to be differentially regulated at a high level of significance. A la  ...[more]

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