Transcriptomics

Dataset Information

335

MicroRNA-132/212 deficiency enhances Ab production and senile plaque deposition in Alzheimer’s disease triple transgenic mice


ABSTRACT: The abnormal regulation of amyloid-b (Ab) metabolism (e.g., production, cleavage, clearance) plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to participate in AD progression are the small regulatory non-coding microRNAs (miRs). In particular, the miR-132/212 cluster is severely reduced in the AD brain. In previous studies we have shown that miR-132/212 deficiency in mice leads to impaired memory and enhanced Tau pathology as seen in AD patients. Here we demonstrate that the genetic deletion of miR-132/212 promotes Ab deposition and amyloid (senile) plaque formation in triple transgenic AD (3xTg-AD) mice. Using RNA-Seq and bioinformatics, we identified genes of the miR-132/212 network with documented roles in the regulation of Ab metabolism, including Tau, Mapk, and Sirt1. We used RNA-Seq to analyse the hippocampus of 3xTg-AD mice lacking the miR-132/212 cluster as well as Neuro2a cells overexpressing miR-132 mimics.

ORGANISM(S): Mus musculus  

SUBMITTER: Sara Rainone   Julia Hernandez-Rapp  Sébastien S Hébert  Sebastien Hebert 

PROVIDER: E-GEOD-84481 | ArrayExpress | 2016-07-17

SECONDARY ACCESSION(S): SRP078692GSE84481PRJNA329416

REPOSITORIES: GEO, ArrayExpress, ENA

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