Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA101555PRJNA105349PRJNA101541PRJNA105351
ORGANISM(S): Mus musculus
SUBMITTER: Shane McManus Meinrad Busslinger
PROVIDER: E-GEOD-8472 | ArrayExpress | 2007-08-23
SECONDARY ACCESSION(S): GSE8472PRJNA101555
REPOSITORIES: GEO, ArrayExpress
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E-GEOD-8472.README.txt | Txt | |||
E-GEOD-8472.idf.txt | Idf | |||
E-GEOD-8472.processed.1.zip | Processed | |||
E-GEOD-8472.sdrf.txt | Txt |
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Immunity 20070719 1
The transcription factor Pax5 represses B lineage-inappropriate genes and activates B cell-specific genes in B lymphocytes. Here we have identified 170 Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes require continuous Pax5 activity for normal expression in pro-B and mature B cells. Expression of half of the Pax5-activated genes is either absent or substantially reduced upon Pax5 loss in plasma cells. Direct Pax5 target genes were identified based on thei ...[more]