Dataset Information


MicroRNAs in adult rodent liver and response to dioxin

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE8467: Micro-RNAs in Adult Rat Liver are Refractory to 19 Hours Dioxin Exposure GSE8468: Micro-RNAs levels in wildtype vs. Ahr-null adult mouse liver constitutively and in response to doxin treatment. GSE8469: Micro-RNAs in Adult Long-Evans (Turku/AB) Rat Liver are Refractory to 96 Hours Dioxin Treatment GSE8470: Micro-RNAs in Adult Rat Liver are Refractory to Dioxin Treatment Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Rattus Norvegicus Mus Musculus

SUBMITTER: Raimo Pohjanvirta   Allan B Okey  Jere Lindén  Trine Celius  Ivy D Moffat  Ivy Moffat  Paul C Boutros 

PROVIDER: E-GEOD-8474 | ArrayExpress | 2007-08-14



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E-GEOD-8474.README.txt Txt
E-GEOD-8474.idf.txt Idf Processed Raw
E-GEOD-8474.sdrf.txt Txt
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microRNAs in adult rodent liver are refractory to dioxin treatment.

Moffat Ivy D ID   Boutros Paul C PC   Celius Trine T   Lindén Jere J   Pohjanvirta Raimo R   Okey Allan B AB  

Toxicological sciences : an official journal of the Society of Toxicology 20070813 2

Dioxin-like chemicals are well known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic analyses in several laboratories indicate that dioxin-like chemicals or AHR genotype itself also can downregulate levels of mRNAs encoded by numerous genes. The mechanism responsible for such downregulation is unknown. We hypothesized that microRNAs (miRNAs), which have emerged as powerful negative regulators of mRNA levels in several systems  ...[more]

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