Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David A Hildeman Kun-Po Li Azeb Haile Christopher Jordan Gamper Elizabeth M Jaffee Christopher J Gamper Jonathan D Powell Alexandra B Pucsek Maggie J Phillips Brian H Ladle
PROVIDER: E-GEOD-85823 | ArrayExpress | 2016-08-20
SECONDARY ACCESSION(S): GSE85823SRP082394PRJNA339495
REPOSITORIES: GEO, ArrayExpress, ENA
Guerrero-Preston Rafael R Michailidi Christina C Marchionni Luigi L Pickering Curtis R CR Frederick Mitchell J MJ Myers Jeffrey N JN Yegnasubramanian Srinivasan S Hadar Tal T Noordhuis Maartje G MG Zizkova Veronika V Fertig Elana E Agrawal Nishant N Westra William W Koch Wayne W Califano Joseph J Velculescu Victor E VE Sidransky David D
Epigenetics 20140501 7
Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet, recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing (MBD-seq), 450K Methylation arrays, whole exome sequencing, and whole genome gene expression arrays in primary head and neck squamous cell carcinoma (HNSCC) tumors and matched uvulopalatopharyngoplast ...[more]