Genomics

Dataset Information

42

The Long Noncoding RNA SNHG1 Regulates both the Local and Distal Genes in Cancer


ABSTRACT: lncRNAs play important roles in various physiological and pathological processes. However, the detailed molecular mechanisms by which lncRNAs act are still incomplete. Here, we functionally characterized the nuclear-enriched lncRNA SNHG1 which is highly expressed in several types of cancer relative to surrounding normal tissues. SNHG1 was regulated by oncogenic factor c-Myc and could promote tumor growth. We found that SNHG1 was involved in the Akt signaling pathway through promoting the neighboring transcription of protein-coding gene SLC3A2 in cis, by binding to the Mediator complex to facilitate enhancer-promoter interaction. Transcriptome analysis further revealed that several stress response genes, as well as signaling pathways, were regulated by SNHG1. Importantly, SNHG1 coordinated the expression of ATF3 through preventing FUBP1 from binding to its upstream regulatory region. Collectively, our findings demonstrate that lncRNA SNHG1 can function both in cis and in trans with distinct mechanisms to promote tumorigenesis and progression. Even, Odd probes targeting SNHG1 sequence, and control probes targeting LacZ. Probes was coupled with biotin, the captured DNA was prepared for library then sequencing.

ORGANISM(S): Homo sapiens  

SUBMITTER: Y Sun   Guifeng Wei  H Luo  G Wei  R Chen 

PROVIDER: E-GEOD-85842 | ArrayExpress | 2016-08-20

SECONDARY ACCESSION(S): SRP082452GSE85842PRJNA339541

REPOSITORIES: GEO, ArrayExpress, ENA

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E-GEOD-85842.additional.1.zip Other
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E-GEOD-85842.idf.txt Idf
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