Transcriptomics,Multiomics

Dataset Information

3

Transcription profiling of mouse 3T3-L1 adipocyte tissue culture treated with CLA


ABSTRACT: Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). Experiment Overall Design: Mouse 3T3-L1 RNA for each time point was isolated from control and treatment samples for analysis on microarrays with two to four biological reps.

INSTRUMENT(S): 418 [Affymetrix]

SUBMITTER: Jean-Jack M. Riethoven  

PROVIDER: E-GEOD-8681 | ArrayExpress | 2008-06-16

SECONDARY ACCESSION(S): GSE8681PRJNA109033

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-8681.README.txt Txt
E-GEOD-8681.eSet.r Other
E-GEOD-8681.idf.txt Idf
E-GEOD-8681.processed.1.zip Processed
E-GEOD-8681.raw.1.zip Raw
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Publications

Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes.

LaRosa P Christopher PC   Riethoven Jean-Jack M JJ   Chen Han H   Xia Yuannan Y   Zhou You Y   Chen Mei M   Miner Jess J   Fromm Michael E ME  

Physiological genomics 20070918 3


Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT) and adipocytes in culture. The early transcriptome changes in treated WAT and 3T3-L1 adipocytes were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Gene expression responses between 4 and 24 h after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). The responses o  ...[more]

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