Transcriptomics

Dataset Information

9

Global profiling of developmental gene expression in Myxococcus xanthus


ABSTRACT: In response to starvation, Myxococcus xanthus initiates a developmental program that results in the formation of spore-filled multicellular fruiting bodies. Here we have used cDNA microarray analysis to determine changes in the global gene expression at different time points of the developmental process. The expression of nearly 900 genes was found to be altered at least two-fold during development as compared to vegetative cells. Genes encoding proteins with typical vegetative functions such as protein synthesis and energy metabolism were transcriptionally down-regulated in the early stages of development. Among the 430 genes transcriptionally up-regulated during development genes with regulatory functions were overrepresented; underlining that fruiting body formation relies on a complex signalling network. Notably, almost 40% of all genes with increased expression at different stages of development encoded hypothetical proteins indicating a large unexplored potential of proteins important for fruiting body formation. Keywords: Time course of development with 9 time points 3 biological replicates each; normalized ratios to vegetative cells of DK1622 (wt) Cy5

ORGANISM(S): Myxococcus xanthus  

SUBMITTER: Reiner Hedderich   Sigrun Wegener-Feldbrügge  Nils Hamann  Lotte Sogaard-Andersen 

PROVIDER: E-GEOD-9477 | ArrayExpress | 2008-01-31

SECONDARY ACCESSION(S): GSE9477PRJNA103249

REPOSITORIES: GEO, ArrayExpress

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Publications

Bioinformatics and experimental analysis of proteins of two-component systems in Myxococcus xanthus.

Shi Xingqi X   Wegener-Feldbrügge Sigrun S   Huntley Stuart S   Hamann Nils N   Hedderich Reiner R   Søgaard-Andersen Lotte L  

Journal of bacteriology 20071109 2


Proteins of two-component systems (TCS) have essential functions in the sensing of external and self-generated signals in bacteria and in the generation of appropriate output responses. Accordingly, in Myxococcus xanthus, TCS are important for normal motility and fruiting body formation and sporulation. Here we analyzed the M. xanthus genome for the presence and genetic organization of genes encoding TCS. Two hundred seventy-two TCS genes were identified, 251 of which are not part of che gene cl  ...[more]

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