Transcriptomics

Dataset Information

4

Transcription profiling of Xenopus hybrid femalesex reversal experiment


ABSTRACT: Gene expression was examined in genetic males that were sex-reversed to be phenotypically female compared to normal hybrid females; We used microarrays to test expression in the gonad of sex-reversed females (ZZ) compared to normal females (ZW) Experiment Overall Design: RNA from the ovary of sexually mature individuals was extracted and hybridized onto Affymetrix microarrays.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Xenopus laevis x Xenopus muelleri  

SUBMITTER: John Malone  

PROVIDER: E-GEOD-9504 | ArrayExpress | 2008-06-16

SECONDARY ACCESSION(S): GSE9504PRJNA105171

REPOSITORIES: GEO, ArrayExpress

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Publications

Physiological sex predicts hybrid sterility regardless of genotype.

Malone John H JH   Michalak P P  

Science (New York, N.Y.) 20080101 5859


Reproductive isolation between biological species is characterized by Haldane's rule, which states that the heterogametic sex (XY or ZW) suffers the most dysfunctional effects of hybridization. It has been hypothesized that, in addition to X-linked recessive genes, Haldane's rule also reflects the faster evolution of genes related to male reproduction (faster-male evolution). We used sex-reversed hybrid Xenopus to test faster-male evolution by examining the fertility of sex-reversed individuals  ...[more]

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